
Twenty thousand data runs
and no statistically SIGNIFICANT results.
The Big Bang Theory Season 2, Episode 13

I owe you a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3

I hear you owe that boy a SIGNIFICANT debt.
Game of Thrones Season 3, Episode 3

Well, you've lived with
your SIGNIFICANT other for some time.
The Big Bang Theory Season 10, Episode 4

If I had another SIGNIFICANT aspect
of my life...
The Big Bang Theory Season 2, Episode 3